What is needed to make low-density lipoprotein transport in human aorta computational models suitable to explore links to atherosclerosis? Impact of initial and inflow boundary conditions

Given that it is not possible to verify in vivo the proper LDL concentration initialization to be applied, we suggest to carefully set and unambiguously declare the imposed BCs and LDL concentration IC when modelling LDL transfer in aorta, in order to obtain reproducible and ultimately comparable results among different laboratories.