Visual targeted therapy of hepatic cancer using homing peptide modified calcium phosphate nanoparticles loading doxorubicin guided by T1 weighted MRI

A novel pH-sensitivity multifunctional calcium phosphate nanoparticles, modified by hepatocarcinoma cells' specific binding polypeptide A54 peptide, loaded with MR contrast agent Gd-DTPA and antitumor drug DOX (A54-CaP/Gd-DTPA/DOX) was successfully designed for T1-weighted MR imaging guiding targeting hepatic cancer therapy.260