کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7238010 1471142 2018 35 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effective intracellular delivery and Th1 immune response induced by ovalbumin loaded in pH-responsive polyphosphazene polymersomes
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Effective intracellular delivery and Th1 immune response induced by ovalbumin loaded in pH-responsive polyphosphazene polymersomes
چکیده انگلیسی
Protein antigen ovalbumin (OVA) was efficiently loaded into pH-sensitive PEDP polymersomes. Then OVA polymersomes were endocytosed by phagocyte cells and the antigen was digested to peptide by proteases in lysosomes. After being released to the cytosol, the peptide combined with MHC (Major Histocompatibility Complex) and the MHC/peptide complex was transported to surface of APC cells and then bonded with the relevant receptor of effector cells. Consequently, the Th1 immune response elicited by the advanced administrated OVA was strong enough to suppress the growth of tumor as a prophylactic vaccine.94
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 14, Issue 5, July 2018, Pages 1609-1618
نویسندگان
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