Nanoimprinting of biomedical polymers reduces candidal physical adhesion

The schematic illustrated a regular-spaced nano-patterned biomaterial with yeast (Y) and germlings (G) attempting to adhere. These cells are coated in cell wall proteins ALS1, ALS3 and EAP1, which are expressed under different conditions in varying amounts depending on morphology. The nano-pits alter the expression of these proteins compared to flat surfaces and irregular spaced nanopits. Overall, these regular spaced pits significantly reduce Y and G adhesion.124