Zinc phthalocyanine encapsulated in polymer micelles as a potent photosensitizer for the photodynamic therapy of osteosarcoma

Zinc phthalocyanine (ZnPc) was successfully loaded in an amphiphilic block copolymer PEG-PMAN consisting of aromatic nicotinate with a high drug loading content and induced the stronger photodynamic cytotoxicity than free ZnPc because of the higher drug uptake rate in tumor cells. The formed ZnPc nanomedicine was evaluated as a potent photosensitizer for the photodynamic therapy of osteosarcoma.151