کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7238610 | 1471144 | 2018 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Physiological uptake and retention of radiolabeled resveratrol loaded gold nanoparticles (99mTc-Res-AuNP) in colon cancer tissue
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Nanoparticles (NPs) 20-30nm in size with a surface coating of resveratrol on gum arabic stabilized gold nanoparticles were synthesized.The NPs were successfully radiolabled with Tc-99m with a lableling efficiency of >90% and injected intravenously into colon tumor bearing rats. Comparing % specific uptake values for 99mTc-Res-AuNP with 99mTc-resveratrol in colon tumors, the values were significantly higher for 99mTc-Res-AuNP.Low reticuloendothelial uptake and slow clearance of the NPs from blood pool improved the bio-availiability and consequently the uptake of radiolabled resveratrol molecules at the target site thus proving the pharmacokinetic effectivness of 99mTc-Res-AuNP over 99mTc-resveratrol for this kind of in vivo application.188
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 14, Issue 3, April 2018, Pages 1059-1071
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 14, Issue 3, April 2018, Pages 1059-1071
نویسندگان
Rozy PhD, Vijayta D. PhD,, D.K. PhD, DMRIT,