A targeted ferritin-microplasmin based thrombolytic nanocage selectively dissolves blood clots

A nanoparticle-based targeted delivery of microplasmin with systemic administration to the thrombus is proposed. Multivalent clot-targeting (CLT) peptides and microplasmin proteins coexist on the surface of the ferritin double chambered nanocage (CLT-sFt-μPn DCNC). The thrombolytic CLT-sFt-μPn nanocage overcomes off-targeting problem of microplasmin and efficiently resolves thrombosis in artery and vein without deleterious bleeding side effects.650