Protein corona and phospholipase activity drive selective accumulation of nanomicelles in atherosclerotic plaques

Phosphatidylcholine-specific phospholipase C selectively modifies the organic coating of magnetic nanomicelles, leading to a change in several physicochemical properties. This enzymatic activity, together with the presence of ApoB-100 in the protein corona of the nanomicelles leads to the in vivo accumulation in the atherosclerotic lesions. This novel approach is used for the non-invasive characterisation of atherosclerosis disease in animal models.348