MUC1 aptamer-targeted DNA micelles for dual tumor therapy using doxorubicin and KLA peptide

A) Being in aqueous media Cholesterol modified hybrid of MUC1 targeted DNA strands self assembles to micelle like structure. B) Co-delivery of DOX and KLA peptide using MUC1 aptamer targeted DNA micelle. Description of the abbreviates: CS: complementary strand. Chl-MUC1 apt: cholestryl modified anti-MUC1 aptamer. KLA-DNA micelle-MUC1: micelle structure composed of KLA peptide and anti-MUC1 aptamer. DOX: doxorubicin. DOX-KLA-DNA micelle-MUC1: micelle structure composed of KLA peptide, anti-MUC1 aptamer and doxorubicin.189