A self-assembly nanodrug delivery system based on amphiphilic low generations of PAMAM dendrimers-ursolic acid conjugate modified by lactobionic acid for HCC targeting therapy

One dendrimeric anticancer prodrug based on low generations of PAMAM dendrimers modified by lactobionic acid and natural product ursolic acid was synthetized successfully named as UA-G0-LA for the first time. Due to the branched structure of nanocarrier PAMAM dendrimers, the prodrug would self-assemble into inerratic globose nanoparticles with well-defined size distribution.123