Lysine-containing cationic liposomes activate the NLRP3 inflammasome: Effect of a spacer between the head group and the hydrophobic moieties of the lipids

In human macrophages, NLRP3 inflammasome has been activated in different levels by a series of lysine-containing cationic liposomes, indicating a structure effect of the composing lipids on the stimulation of innate immune system.164