Anticancer potential of ZnO nanoparticle-ferulic acid conjugate on Huh-7 and HepG2 cells and diethyl nitrosamine induced hepatocellular cancer on Wistar albino rat

Hepatocellular carcinoma (HCC) is the primary malignant hepatoma, the incident rates have been increases rapidly for the past few years. Currently, nanoparticle based combination chemotherapy is a blooming area of conventional chemotherapy which is an overwhelming tailored therapeutic approach for HCC. We have conjugated ZnO nanoparticles (ZnONPs) with ferulic acid (ZnONPs-FAC) with simple and cost effective methods, further we demonstrate in vitro and in vivo anticancer efficacy ZnONPs, FA and ZnONPs-FAC on Huh-7 and HepG2 liver cancer cells and in DEN induced HCC model, the result divulged that ZnONPs-FAC has shown synergetic anticancer effect.276