MiR-375 delivered by lipid-coated doxorubicin-calcium carbonate nanoparticles overcomes chemoresistance in hepatocellular carcinoma

Schematic illustration, proposed mechanism and TEM images of LCC-DOX/miR-375 NPs. (A) Schematic showing the compositions of LCC-DOX/miR-375 NPs; (B) proposed mechanism of LCC-DOX/miR-375 NPs for additive anti-tumor effects and reversing drug-resistance in HCC; (C) TEM image of LCC-DOX cores coated with DOPA; (D) and (E) TEM images of LCC-DOX cores coated with DOTAP and DSPE-PEG without (D) and with (E) negative staining. Arrows in (E) show lipid bilayer surrounding the LCC-DOX cores.434