Effect of lipidated gonadotropin-releasing hormone peptides on receptor mediated binding and uptake into prostate cancer cells in vitro

Our work provides evidence that lipidated GnRH-1 analogues facilitated specific uptake by GnRH-receptor positive cancer cells, but not GnRH-receptor negative cells. Additionally, this study shows that non-specific binding was increased when a lipid was present in the compound but did not lead to cellular internalisation.73