کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7278462 | 1473857 | 2016 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Surprising sequential effects on MMN
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
The mismatch negativity (MMN) is conceptualized as a confidence-weighted error signal elicited when a deviation violates the predicted next-state based on regularity. The mechanisms underpinning its generation remain contentious. Smaller MMN response is a robust finding in schizophrenia and reduced amplitude may implicate impairment in prediction-error signalling. An enriched understanding of factors that influence MMN size in healthy people is a prerequisite for translating the relevance of reduced MMN in schizophrenia. This paper features two studies designed to explore factors that impact MMN in healthy individuals. Study 1 confirms that MMN amplitude does not faithfully reflect transition statistics and is susceptible to order-driven bias. In study 2, we demonstrate that an order-driven bias remains despite repeated encounters with sound sequences. These data demonstrate that factors that impact on MMN size in non-clinical groups are not fully understood and that some mechanisms driving relevance filtering are likely influenced by 'top-down' expectations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychology - Volume 116, April 2016, Pages 47-56
Journal: Biological Psychology - Volume 116, April 2016, Pages 47-56
نویسندگان
Jade D. Frost, István Winkler, Alexander Provost, Juanita Todd,