کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7278655 1473869 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Toward a translational approach to targeting the endocannabinoid system in posttraumatic stress disorder: A critical review of preclinical research
ترجمه فارسی عنوان
به سوی یک رویکرد ترجمه به هدف قرار دادن سیستم اندوکانانبینیو در اختلال استرس پس از سانحه: بررسی انتقادی از تحقیقات پیش از موعد
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی
Despite the lack of clinical research, marijuana and synthetic cannabinoids have been approved to treat posttraumatic stress disorder (PTSD) in several states in the United States. This review critically examines preclinical research on the endocannabinoid system (ECS) in order to evaluate three key questions that are relevant to PTSD: (1) Does ECS dysfunction impact fear extinction? (2) Can stress-related symptoms be prevented by ECS modulation? (3) Is the ECS a potential target for enhancing PTSD treatment? Disruption of the ECS impaired fear extinction in rodents, and ECS abnormalities have been observed in PTSD. Targeting fear memories via the ECS had mixed results in rodents, whereas augmented cannabinoid receptor activation typically facilitated extinction. However, the translational value of these findings is limited by the paucity and inconsistency of human research. Further investigation is necessary to determine whether incorporating cannabinoids in treatment would benefit individuals with PTSD, with cautious attention to risks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychology - Volume 104, January 2015, Pages 8-18
نویسندگان
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