کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7283261 1474002 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pragmatic abilities in multiple sclerosis: The contribution of the temporo-parietal junction
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Pragmatic abilities in multiple sclerosis: The contribution of the temporo-parietal junction
چکیده انگلیسی
Recent studies showed that multiple sclerosis (MS) patients might experience communicative deficits, specifically in pragmatics (i.e., the ability to integrate the context-dependent aspects of language). A crucial region for pragmatics is the temporo-parietal junction, in particular the so-called Geschwind's area (GA), which is involved in high-level language processes, including the comprehension of narratives, metaphor, and irony. We evaluated the relationship between pragmatic abilities, measured through the Assessment of Pragmatic Abilities and Cognitive Substrates (APACS) test, and the functional connectivity (FC) of the bilateral GAs, assessed through a seed-based analysis of Resting-State fMRI in patients with MS. A positive correlation was observed between APACS scores and the FC for both the right and the left GA and the paracingulate cortex. Our findings suggest that the brain FC for social communication involves connections extending over both hemispheres, including right and left GAs and right and left paracingulate cortex, possibly impaired in patients with MS. This study offers preliminary evidence for future researches enrolling also a control sample to explore the involvement of GA in pragmatics in neurological disorders as well as in healthy conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Language - Volume 185, October 2018, Pages 47-53
نویسندگان
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