کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7300183 1475163 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gastrin-releasing peptide receptor signaling in the integration of stress and memory
ترجمه فارسی عنوان
گیرنده پپتیدهای آزاد کننده گاسترین در برقراری ادغام استرس و حافظه سیگنال می دهد
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی
Neuropeptides act as signaling molecules that regulate a range of aspects of brain function. Gastrin-releasing peptide (GRP) is a 27-amino acid mammalian neuropeptide, homolog of the amphibian peptide bombesin. GRP acts by binding to the GRP receptor (GRPR, also called BB2), a member of the G-protein coupled receptor (GPCR) superfamily. GRP produced by neurons in the central nervous system (CNS) plays a role in synaptic transmission by activating GRPRs located on postsynaptic membranes, influencing several aspects of brain function. Here we review the role of GRP/GRPR as a system mediating both stress responses and the formation and expression of memories for fearful events. GRPR signaling might integrate the processing of stress and fear with synaptic plasticity and memory, serving as an important component of the set of neurobiological systems underlying the enhancement of memory storage by aversive information.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 112, July 2014, Pages 44-52
نویسندگان
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