کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7300452 | 1475170 | 2013 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular and cellular mechanisms of dopamine-mediated behavioral plasticity in the striatum
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Molecular and cellular mechanisms of dopamine-mediated behavioral plasticity in the striatum Molecular and cellular mechanisms of dopamine-mediated behavioral plasticity in the striatum](/preview/png/7300452.png)
چکیده انگلیسی
The striatum is the input structure of the basal ganglia system. By integrating glutamatergic signals from cortical and subcortical regions and dopaminergic signals from mesolimbic nuclei the striatum functions as an important neural substrate for procedural and motor learning as well as for reward-guided behaviors. In addition, striatal activity is significantly altered in pathological conditions in which either a loss of dopamine innervation (Parkinson's disease) or aberrant dopamine-mediated signaling (drug addiction and L-DOPA induced dyskinesia) occurs. Here we discuss cellular mechanisms of striatal synaptic plasticity and aspects of cell signaling underlying striatum-dependent behavior, with a major focus on the neuromodulatory action of the endocannabinoid system and on the role of the Ras-ERK cascade.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 105, October 2013, Pages 63-80
Journal: Neurobiology of Learning and Memory - Volume 105, October 2013, Pages 63-80
نویسندگان
Milica Cerovic, Raffaele d'Isa, Raffaella Tonini, Riccardo Brambilla,