Transgenic mice over-expressing endothelial endothelin-1 show cognitive deficit with blood-brain barrier breakdown after transient ischemia with long-term reperfusion

- TET-1 mice showed increased anxiety after transient MCAO with 7 days reperfusion.
- TET-1 mice showed cognitive deficit after transient MCAO with 7 days reperfusion.
- Severe BBB breakdown was detected in TET-1 mice after ischemic/reperfusion injury.
- Increased apoptosis were found in the hippocampus of TET-1 mice after the injury.