Involvement of the CA1 GABAA receptors in ACPA-induced impairment of spatial and non-spatial novelty detection in mice

► ACPA decreases spatial change detection and reaction to non-spatial novelty. ► Bicuculline (intra-CA1) did not alter spatial and non-spatial memory. ► Muscimol (intra-CA1) impaired spatial and non-spatial memory. ► Bicuculline restored ACPA-induced spatial and non-spatial memory deficit. ► Muscimol only potentiated spatial memory deficit by ACPA but not non-spatial memory.