Histone acetylation rescues contextual fear conditioning in nNOS KO mice and accelerates extinction of cued fear conditioning in wild type mice

► A single injection of NaB reversed contextual memory deficit in nNOS(-/-) mice. ► A single injection of NaB accelerated extinction of cued memory of wild-type mice. ► NaB had no effect on extinction of cued memory of nNOS(-/-) mice. ► NaB-induced H3 histone acetylation in nNOS(-/-) was greater than in wild-type mice. ► NaB-induced H4 histone acetylation was similar in nNOS(-/-) and wild-type mice.