Participation of hippocampal cholinergic system in memory persistence for inhibitory avoidance in rats

► Medial septum inactivation 12 h post training prevents memory persistence in IA. ► Scopolamine, a mAChRs blocker, hinders memory persistence. ► Specific M1 blockade on hippocampus 12 h post training impairs memory persistence. ► Mecamelamine infusion on hippocampus 12 h post training prevents memory persistence.