Behavioural state differentially engages septohippocampal cholinergic and GABAergic neurons in R6/1 Huntington's disease mice

► Circadian rhythm affects hippocampus-dependent cognition deficits in R6/1 HD mice. ► Circadian rhythm affects cholinergic and GABAergic septohippocampal activity in wildtype mice. ► Behavioural state differentially affects GABAergic septohippocampal activity in R6/1 mice. ► Behavioural state differentially affects hippocampal neuronal activity in R6/1 mice.