Angiotensin-(1-7)/Mas axis integrity is required for the expression of object recognition memory

► Ang-(1-7)/Mas axis is essential for normal ORM processing. ► Mas knockout did not affect the performance of mice in the inhibitory avoidance task. ► Blocking receptor Mas into the hippocampus impaired object recognition memory. ► Blocking of AT1, but not AT2, receptors prevents the ORM deficit of MasKo. ► MasKo has high levels of hippocampal Ang-(1-7), but not Ang I or Ang II.