Mitogen-activated protein kinase in the amygdala plays a critical role in lithium chloride-induced taste aversion learning

► Conditioned taste aversion (CTA) involves activation of the amygdala by toxins. ► Activated phosphorylated MAP kinase (pMAPK) may be a critical intracellular signal. ► LiCl induced pMAPK in the central n. of the amygdala and n. of the solitary tract. ► MEK inhibition by SL327 in the amygdala attenuated CTA and pMAPK induction.