Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways

► Ursolic acid (UA) is a plant-derived pentacyclic triterpenoid. ► UA is reported to possess multiple biological functions. ► Our findings indicate that UA may protect against LPS-induced cognitive deficits. ► Effects of UA are mediated by blocking p38 MAPK and NF-κB signaling activation. ► These data suggest that UA could be recommended as an anti-brain inflammation agent.