Impaired appetitively as well as aversively motivated behaviors and learning in PDE10A-deficient mice suggest a role for striatal signaling in evaluative salience attribution

► PDE10A knockout mice show impaired appetitive and aversive conditioning. ► PDE10A knockout mice show spatial learning deficits in the Morris water maze. ► PDE10A depletion leads to increased zif268 expression in striatum and anterior cingulate cortex.