Glucocorticoids are required for extinction of predator stress-induced hyperarousal

► Repeated exposure to stress context extinguishes predator stress-induced contextual fear memories. ► Repeated exposure to stress context extinguishes predator stress-induced hyperarousal. ► Meytrapone prevented extinction of predator stress-induced hyperarousal. ► Our data suggest that decreased glucocorticoids may contribute to a core symptom of PTSD.