کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7301292 1475187 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats
چکیده انگلیسی
► CMP X and CMP Y are two novel and highly selective 5-HT6 receptor antagonists. ► CMP X and CMP Y improved scopolamine-induced deficits in tests for episodic memory. ► Donepezil and reference 5-HT6 antagonist GSK-742457 also improved performance. ► Co-adm. of CMP X, CMP Y with donepezil resulted in additive cogn. enhancing effects. ► 5-HT6 antagonists could have potential as adjunctive therapy to donepezil.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 96, Issue 2, September 2011, Pages 392-402
نویسندگان
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