Expression of VGLUTs contributes to degeneration and acquisition of learning and memory

► VGLUT1 protein expression decreased in the brain of SAMP8 with aging. ► VGLUT2 protein expression decreased in the brain of SAMP8 with aging. ► VGLUT1 expression increased in the brain of mouse after shuttle-box test. ► VGLUT1 protein expression has the positive correlation with cognitive ability. ► VGLUT2 protein expression has the positive correlation with cognitive ability.