کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7301894 1475283 2018 58 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A critical review of brain and cognitive reserve in Huntington's disease
ترجمه فارسی عنوان
بررسی انتقادی مغز و ذخایر شناختی در بیماری هانتینگتون
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی
The 'reserve' hypothesis posits that the brain undergoes structural and functional reorganisation to actively cope with brain damage or disease. Consistent with passive and active components of 'reserve', the brain moderates its biological substrates (brain reserve) and differentially changes the level of neural activity in tasks-specific networks and/or by recruiting additional non-task related brain regions (cognitive reserve) to optimise behavioural performance. How the 'reserve' hypothesis applies in neurodegenerative disorders such as Huntington's disease (HD) remains unknown. We postulate that unless the 'reserve' hypothesis is tested empirically, it is impossible to draw firm conclusions about how task-related neural activity is providing a neuroplastic change in HD and possibly other neurodegenerative disorders. We conclude that there is a pressing need to operationalise cognitive reserve, as well as incorporate different biological substrates into a model of 'reserve'. We suggest that it is important to identify and embed potential neuroprotective modulating factors of 'reserve' in randomised controlled multi-domain non-pharmaceutical interventions to potentially enhance 'reserve' and thus preserve cognitive and psychosocial functioning in HD patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 88, May 2018, Pages 155-169
نویسندگان
, , , ,