کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7303453 | 1475316 | 2015 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anterior thalamic nuclei lesions and recovery of function: Relevance to cognitive thalamus
ترجمه فارسی عنوان
ضایعات هسته تالام قدامی و بازیابی تابع: مربوط به تالام شناختی
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Injury to the anterior thalamic nuclei (ATN) and their neural connections is the most consistent neuropathology associated with diencephalic amnesia. ATN lesions in rats produce memory impairments that support a key role for this region within an extended hippocampal system of complex overlapping neural connections. Environmental enrichment is a therapeutic tool that produces substantial, although incomplete, recovery of memory function after ATN lesions, even after the lesion-induced deficit has become established. Similarly, the neurotrophic agent cerebrolysin, also counters the negative effects of ATN lesions. ATN lesions substantially reduce c-Fos expression and spine density in the retrosplenial cortex, and reduce spine density on CA1 neurons; only the latter is reversed by enrichment. We discuss the implications of this evidence for the cognitive thalamus, with a proposal that there are genuine interactions among different but allied thalamo-cortical systems that go beyond a simple summation of their separate effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 54, July 2015, Pages 145-160
Journal: Neuroscience & Biobehavioral Reviews - Volume 54, July 2015, Pages 145-160
نویسندگان
John C. Dalrymple-Alford, Bruce Harland, Elena A. Loukavenko, Brook Perry, Stephanie Mercer, David A. Collings, Katharina Ulrich, Wickliffe C. Abraham, Neil McNaughton, Mathieu Wolff,