The vigilance regulation model of affective disorders and ADHD

► VIGALL is an EEG-based tool to assess regulation of vigilance (“brain arousal”). ► Mania is typically associated with unstable, depression with hyperstable vigilance. ► Symptoms in mania and ADHD have a vigilance stabilising function. ► The antimanic effect of stimulants is presently studied in an international RCT. ► The pathogenetic role of LC hyperactivity in depression is discussed.