کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7304027 1475324 2014 24 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: Impact of mouse models
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: Impact of mouse models
چکیده انگلیسی
Disrupted-In-Schizophrenia-1 (DISC1) has captured much attention because it predisposes individuals to a wide range of mental illnesses. Notably, a number of genes encoding proteins interacting with DISC1 are also considered to be relevant risk factors of mental disorders. We reasoned that the understanding of DISC1-associated mental disorders in the context of network principles will help to address fundamental properties of DISC1 as a disease gene. Systematic integration of behavioural phenotypes of genetic mouse lines carrying perturbation in DISC1 interacting proteins would contribute to a better resolution of neurobiological mechanisms of mental disorders associated with the impaired DISC1 interactome and lead to a development of network medicine. This review also makes specific recommendations of how to assess DISC1 associated mental disorders in mouse models and discuss future directions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 45, September 2014, Pages 271-294
نویسندگان
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