کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
730489 | 892978 | 2012 | 7 صفحه PDF | دانلود رایگان |
This paper deals with problems that have to be faced when performing mass and temperature measurements of substances subjected to freeze-drying processes. A brief description of a lyophilization process is initially presented and a deep investigation is performed in order to identify the main uncertainty contributions that affect mass and temperature measurements. A measurement system is then described that has been specifically conceived to work inside a freeze-dryer. Experimental results are reported that refer to the metrological characterization of the proposed measurement system and to its use for the monitoring of real freeze-drying processes. Experimental tests are also described that have been conceived to estimate the uncertainty contributions strictly related to this specific application.
► Freeze-drying process review to highlight the main uncertainty contributions.
► Measurement system specifically conceived to operate in a harsh environment.
► Mass and temperature uncertainty estimation in freeze-drying processes.
► Experimental results related to characterization and use of the proposed system.
► Main uncertainty contribution mainly due to the definitional uncertainty.
Journal: Measurement - Volume 45, Issue 7, August 2012, Pages 1706–1712