A high sensitive square wave voltammetric sensor based on ZnO nanoparticle ionic liquid paste electrode for determination of benserazide in biological samples

• Synthesis of ZnO nanoparticles and investigation of synthesized nanoparticles by SEM and XRD.
• Preparation of ZnO nanoparticles/ionic liquid paste electrode (ZnO/ILCPE).
• Investigation of electrochemical behavior of benserazide on ZnO/ILCPE.
• Determination of benserazide in urine and serum samples.

In this work, ZnO nano particles were synthesized and their characteristics were investigated by scanning electron microscopy and X-ray powder diffraction. ZnO nano particles and a synthesized ionic liquid (1-Methyl-3-butylimidazolium bromide) were applied to modification of carbon paste electrode. Electrochemical behavior of benserazide (BA) was studied at modified electrode. Under optimum pH of 6.0, the relation between oxidation current and concentration of BA was linear in the range of 0.1–430.0 μmol L−1 BA. Detection limit of method was calculated to be 0.06 μmol L−1 BA. Effects of potential interferences on determination of BA were investigated and proposed method was used for determination of BA in biological samples.