کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7313188 | 1475454 | 2016 | 42 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Visual short-term memory binding deficit in familial Alzheimer's disease
ترجمه فارسی عنوان
کوتاه مدت حافظه کوتاه مدت در بیماران مبتلا به آلزایمر خانوادگی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Overall, FAD mutation carriers were worse than controls for object identity as well as in gross localization memory performance. Moreover, they showed greater misbinding of object identity and location than healthy controls. Thus they would often mislocalize a correctly-identified item to the location of one of the other items held in memory. Significantly, asymptomatic gene carriers - who performed similarly to healthy controls on standard neuropsychological tests - had a specific impairment in object-location binding, despite intact memory for object identity and location. Consistent with the hypothesis that the hippocampus is critically involved in relational binding regardless of memory duration, decreased hippocampal volume across FAD participants was significantly associated with deficits in object-location binding but not with recall precision for object identity or localization. Object-location binding may therefore provide a sensitive cognitive biomarker for MTL dysfunction in a range of diseases including AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cortex - Volume 78, May 2016, Pages 150-164
Journal: Cortex - Volume 78, May 2016, Pages 150-164
نویسندگان
Yuying Liang, Yoni Pertzov, Jennifer M. Nicholas, Susie M.D. Henley, Sebastian Crutch, Felix Woodward, Kelvin Leung, Nick C. Fox, Masud Husain,