کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7320732 | 1475587 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The impact of epileptiform abnormalities and hippocampal lesions on retention of recent autobiographical experiences: Adding insult to injury?
ترجمه فارسی عنوان
تأثیر ناهنجاریهای صرعی و ضایعات هیپوکامپ بر حفظ تجربیات اخباری از خودباوری: اضافه کردن توهین به آسیب؟
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کلمات کلیدی
فراموشی مدتها طول می کشد، صرع، حافظه اتفاقی، حافظه اپیزودیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Accelerated long term forgetting (ALF), whereby information is rapidly lost over days or weeks has been noted in patients with epileptic conditions. The present study sought to determine which clinical factors underlie such consolidation failure for recent autobiographical experiences in patients with focal epilepsy. We enrolled 21 patients with temporal lobe epilepsy (TLE), with and without hippocampal lesions (TLE(+)=12; TLE(â)=9, respectively), 11 patients with extratemporal epilepsy (ETE) and 29 controls (NC). Recall and recognition were tested at different delays (i.e., 30Â min, 24Â h and 4 days). During the study interval, most of the patients underwent concurrent ambulatory EEG monitoring. Analyses of variance indicated GroupÃDelay interval interactions for recall. The TLE(+) group showed significant decline in recall by 24Â h delay. On recognition Group by Delay interval was not detected but main effect for Group revealed that the ETE group demonstrated ALF on recognition questions over the interval between 24Â h and 4 days. Regression analyses confirmed that a hippocampal lesion was particularly disruptive to consolidation over the first 24Â h, and that seizures were associated with memory decline over longer delays. Our findings show that the retention of autobiographical experiences involves multiple mechanisms, which operate over different timeframes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropsychologia - Volume 66, January 2015, Pages 259-266
Journal: Neuropsychologia - Volume 66, January 2015, Pages 259-266
نویسندگان
Monica Ricci, Armin Mohamed, Greg Savage, Janet Boserio, Laurie A. Miller,