کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7321009 | 1475591 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The anatomy of visuospatial construction revealed by lesion-symptom mapping
ترجمه فارسی عنوان
آناتومی ساختاری فضایی نشان داده شده توسط نقشه برداری ضایعه
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کلمات کلیدی
ADCFDRROCFJudgment of line orientationMNIVLSMDWIDSCFunctional MRI - افامآرآی یا تصویرسازی تشدید مغناطیسی کارکردیdiffusion-weighted imaging - تصویربرداری با وضوح تصویربرداریfMRI - تصویرسازی تشدید مغناطیسی کارکردیvisuospatial perception - درک متقابلapparent diffusion coefficient - ضریب انتشار آشکارDice similarity coefficient - ضریب تشابه تاسLesion studies - مطالعات زخمMontreal Neurological Institute - موسسه عصبی مونترالfalse discovery rate - میزان کشف کاذبLesion-symptom mapping - نقشه برداری از علائم زخمVoxel-based lesion-symptom mapping - نقشه برداری ضایعه مبتنی بر وکسل
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Visuospatial construction is a complex cognitive operation that is composed of a purely constructional component (visuoconstruction proper), and visuoperceptive, attentional, and decision-making components. The anatomical correlates of visuospatial construction and its cognitive subcomponents are poorly understood. The purpose of the present study was to determine the anatomical correlates of visuospatial construction by applying lesion-symptom mapping in a cohort of 111 patients with first-ever ischemic stroke. We employed the Rey-Osterrieth Complex Figure (ROCF) copy test and the Judgment of Line Orientation (JLO); both tests measure visuoperception, while only the ROCF has a constructional component. We first performed assumption-free voxel-based lesion-symptom mapping, which revealed large shared right hemispheric correlates for the ROCF and JLO in the frontal lobe, superior temporal lobe, and supramarginal gyrus. These shared anatomical correlates reflect the visuoperceptive component of the ROCF and JLO. Anatomical correlates were discordant in the right superior parietal lobule, and angular and middle occipital gyri: lesions in these regions were associated with poor performance on the ROCF, but not the JLO. Secondly, these findings were reproduced with a region of interest-based analysis that yielded a statistically significant correlation between infarct volume in the right inferior and superior parietal, angular and middle occipital cortices, and poor performance on the ROCF, but not the JLO. This discordance in anatomical correlates of the ROCF and JLO reflects the visuoconstructive component of the ROCF. These findings provide new insights in the anatomical correlates of the visuoperceptive and visuoconstructive components of the ROCF and provide evidence for a crucial role of the right inferior and superior parietal, angular and middle occipital gyri in visuoconstruction proper.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropsychologia - Volume 62, September 2014, Pages 68-76
Journal: Neuropsychologia - Volume 62, September 2014, Pages 68-76
نویسندگان
J. Matthijs Biesbroek, Martine J.E. van Zandvoort, Hugo J. Kuijf, Nick A. Weaver, L. Jaap Kappelle, Pieter C. Vos, Birgitta K. Velthuis, Geert Jan Biessels, Albert Postma, On behalf of the Utrecht VCI study group On behalf of the Utrecht VCI study group,