کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7321977 | 1475600 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of dopaminergic medication on dynamic decision making in Parkinson's disease
ترجمه فارسی عنوان
اثرات داروهای دوپامینرژیک بر تصمیم گیری پویا در بیماری پارکینسون
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کلمات کلیدی
پیش بینی، مداخله، تصمیم گیری پویا، فرضیه بیش از حد دوپامین، یادگیری،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
In the present study we address the following questions: (1) How is performance affected when patients with Parkinson's Disease (PD) perform a dynamic decision making task? (2) Does dopaminergic medication differentially affect dynamic decision making? To address these questions participants were trained with different goals during learning: either they made intervention-based decisions or prediction-based decisions during learning. The findings show that overall there is an advantage for those trained to intervene over those trained to predict. In addition, the results are the first demonstration that PD patients 'ON' (N=20) compared to 'OFF' L-Dopa (N=15) medication and also relative to healthy age matched controls (N=16) showed lower levels of relative improvement in the accuracy of their decisions in a dynamic decision making task, and tended to use sub-optimal strategies. These findings provide support for the 'Dopamine Overdose' hypothesis using a novel decision making task, and suggest that executive functions such as decision making can be adversely affected by dopaminergic medication in PD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropsychologia - Volume 53, January 2014, Pages 157-164
Journal: Neuropsychologia - Volume 53, January 2014, Pages 157-164
نویسندگان
Magda Osman, Agata Ryterska, Kash Karimi, LingLing Tu, Ignacio Obeso, Maarten Speekenbrink, Marjan Jahanshahi,