The Met-genotype of the BDNF Val66Met polymorphism is associated with reduced Stroop interference in elderly

► Met-allele of the Val66Met polymorphism is related to lower Stroop interference in elderly. ► Lower Stroop susceptibility was associated with larger centro-parietal N450 in incompatible trials. ► Preparatory processes and several neuropsychological parameters were not affected by the BDNF Val66Met genotype. ► Enhanced inhibitory control in the Met-genotype is discussed within the framework of fronto-striatal networks.