کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7374816 1480065 2018 28 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A new method for shrinking tumor based on microenvironmental factors: Introducing a stochastic agent-based model of avascular tumor growth
ترجمه فارسی عنوان
یک روش جدید برای کاهش تومور بر اساس عوامل میکرو محیطی: معرفی یک مدل مبتنی بر عامل تصادفی از رشد تومورهای مغزی
کلمات کلیدی
مدل ریاضی، مدل مبتنی بر عامل تصادفی رشد تومور، درمان
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات فیزیک ریاضی
چکیده انگلیسی
In this paper, by using cellular automata formalism, a two-dimensional stochastic agent-based model for avascular tumor growth is presented. The model is based on biological assumptions, physical structure, agents and their states, and transition rules. The interaction between immune and cancer cells is probabilistic. The immune cell recruitment, which usually occurs after the detection of tumor cells, is considered. The insights gain in the proposed work to model the immune-tumor interaction is of great importance to control the tumor growth via micro-environment factors. The parameters used in the present model are in compatible with cancer biology using in vivo experimental data. The results show that the proposed model not only is able to simulate the tumor growth graphically, but also the in vivo tumor growth quantitatively and qualitatively. In this paper, by introducing a new concept; critical point, a new idea is proposed to shrink the tumor or slow down its growth rate. The tumor will grow slowly if the division probability of the proliferative tumor cells depends on the microenvironmental conditions. The proposed idea has been validated using an in silico simulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 508, 15 October 2018, Pages 771-787
نویسندگان
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