کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7375062 | 1480067 | 2018 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
On the learning control effects in the cancer-immune system competition
ترجمه فارسی عنوان
در اثرات کنترل یادگیری در رقابت سیستم ایمنی سرطان
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کلمات کلیدی
نظریه جنبشی، ترموستات، شبیه سازی مستقیم مونت کارلو، تعاملات سلولی،
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
فیزیک ریاضی
چکیده انگلیسی
The interactions between a tumor and the immune system are modeled at cell scale in the framework of thermostatted kinetic theory. Cell activation and learning are reproduced by the increase of cell activity during interactions. The second moment of the activity of the whole system is controlled by a thermostat which reproduces the regulation of the learning process and memory loss through cell death. An algorithm inspired from the direct simulation Monte Carlo (DSMC) method is used to simulate stochastic trajectories for the numbers of cells and to study the sensitivity of the dynamics to various parameters. The nonintuitive role played by the thermostat is pointed out. For inefficient thermalization, the divergence of the number of cancer cells is obtained in spite of favored production of immune system cells. Conversely, when the activity fluctuations are controlled, the development of cancer is contained even for weakened immune defenses. These results may be correlated to unexpected clinical observations in the case of different cancers, such as carcinoma, lymphoma, and melanoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 506, 15 September 2018, Pages 462-475
Journal: Physica A: Statistical Mechanics and its Applications - Volume 506, 15 September 2018, Pages 462-475
نویسندگان
Léon Masurel, Carlo Bianca, Annie Lemarchand,