کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7375956 1480077 2018 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The maximum entropy production and maximum Shannon information entropy in enzyme kinetics
ترجمه فارسی عنوان
حداکثر تولید آنتروپی و حداکثر آنتروپی اطلاعات شانون در سینتیک آنزیم
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات فیزیک ریاضی
چکیده انگلیسی
We demonstrate that the maximum entropy production principle (MEPP) serves as a physical selection principle for the description of the most probable non-equilibrium steady states in simple enzymatic reactions. A theoretical approach is developed, which enables maximization of the density of entropy production with respect to the enzyme rate constants for the enzyme reaction in a steady state. Mass and Gibbs free energy conservations are considered as optimization constraints. In such a way computed optimal enzyme rate constants in a steady state yield also the most uniform probability distribution of the enzyme states. This accounts for the maximal Shannon information entropy. By means of the stability analysis it is also demonstrated that maximal density of entropy production in that enzyme reaction requires flexible enzyme structure, which enables rapid transitions between different enzyme states. These results are supported by an example, in which density of entropy production and Shannon information entropy are numerically maximized for the enzyme Glucose Isomerase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 496, 15 April 2018, Pages 220-232
نویسندگان
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