کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7377101 1480112 2016 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mathematical model for drug molecules encapsulated in lipid nanotube
ترجمه فارسی عنوان
مدل ریاضی برای مولکول های دارو که در نانولوله های چرب کپسوله شده اند
کلمات کلیدی
نانولوله های لیپیدی، دوکسوروبیسین، پتانسیل لنارد جونز، انرژی مکش،
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات فیزیک ریاضی
چکیده انگلیسی
Lipid nanotube is considered as a nanocontainer for drug and gene delivery. It is important to understand a basic idea of the encapsulation process. In this paper, we use the Lennard-Jones potential function and the continuous approximation to explain the energy behaviour of three hollow shapes of Doxorubicin (DOX) clusters that are a sphere, a cylinder, and an ellipsoid interacting with the lipid nanotube. On assuming that the surface areas of the three structures are equal, we can find the minimum size of the lipid nanotube that encapsulates DOX inside by determining the suction energy. Moreover, we find that a long cylindrical drug provides the largest suction energy among other structures studied here due to the perfect fit between the cylindrical drug and the cylindrical tube. This investigation is the first step to develop the design of nanocapsule for medical application.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 461, 1 November 2016, Pages 46-60
نویسندگان
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