کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7382043 1480179 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Systematic detection of hidden complexities in the unfolding mechanism of a cytosine-rich DNA strand
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات فیزیک ریاضی
پیش نمایش صفحه اول مقاله
Systematic detection of hidden complexities in the unfolding mechanism of a cytosine-rich DNA strand
چکیده انگلیسی
We investigate the unfolding pathway of a cytosine-rich DNA structure via molecular dynamics simulations. By the study of the essential dynamics, we are able to identify a hidden complexity in the description of the dynamics in terms of the first two eigenvectors which are used as collective variables. This complexity can be mainly explained by non-Gaussian fluctuations due to contributions arising from the disregarded set of eigenvectors. We introduce the local non-Gaussian parameter as a tool for the detection of hidden complexities. The usage of this parameter allows a fast and reliable investigation for the determination of the important minimal number of eigenvectors which is needed for a sufficient description of molecular unfolding motion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 394, 15 January 2014, Pages 136-144
نویسندگان
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