کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
743991 | 1462123 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effect of DNA probe distribution on the reliability of label-free biosensors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The effect of DNA probe distribution on the reliability of label-free biosensors The effect of DNA probe distribution on the reliability of label-free biosensors](/preview/png/743991.png)
چکیده انگلیسی
As the design of label-free DNA biosensors matures, and their sizes reduced to enhance their sensitivity, not much has been researched about the variations in the received signal with the positioning of the probes on the sensitive surface. We approach this issue computationally in this paper. By adopting the finite-element model on a three-dimensional biological field-effect transistor (BioFET) slice, and running Monte-Carlo simulations on the positions of the DNA molecules, we extract the expected variations in the signal. Then, we show that signal-to-noise (SNR) ratio can be low enough to hinder the functionality of the device, placing a limitation on how low the sensitivity of a sensor of a certain size can be.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 160, Issue 1, 15 December 2011, Pages 441–447
Journal: Sensors and Actuators B: Chemical - Volume 160, Issue 1, 15 December 2011, Pages 441–447
نویسندگان
M.W. Shinwari, M.F. Shinwari, M.J. Deen, P.R. Selvaganapathy,