کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7585361 1492037 2018 29 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Persimmon vinegar polyphenols protect against hydrogen peroxide-induced cellular oxidative stress via Nrf2 signalling pathway
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Persimmon vinegar polyphenols protect against hydrogen peroxide-induced cellular oxidative stress via Nrf2 signalling pathway
چکیده انگلیسی
Since polyphenols are known to exhibit antioxidative properties, we prepared and characterized persimmon vinegar polyphenols (PVP) in this study. Furthermore, we investigated the protective effect of PVP on hydrogen peroxide (H2O2)-induced oxidative stress in HepG2 cells and its underlying mechanisms. Our results showed that flavon-3-ols were the predominant polyphenols in PVP. Pre-treatment with PVP significantly decreased (p < 0.05) H2O2-induced cell damage in a dose-dependent manner, accompanied by decrease in lactate dehydrogenase (LDH) leakage, aminotransferase activities, and ROS accumulation. Moreover, PVP upregulated the expression of antioxidative enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H: quinone oxidoreductase 1 (NQO1), and increased the levels of glutathione. Western blotting results showed that PVP induced the nuclear translocation of nuclear factor (erythroid-derived-2)-related factor 2 (Nrf2). Taken together, our results indicated that PVP effectively protected HepG2 cells against oxidative stress via activation of the Nrf2 antioxidative pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 255, 30 July 2018, Pages 23-30
نویسندگان
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