کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7591278 | 1492105 | 2015 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
New steroidal saponins and antiulcer activity from Solanum paniculatum L.
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: New steroidal saponins and antiulcer activity from Solanum paniculatum L. New steroidal saponins and antiulcer activity from Solanum paniculatum L.](/preview/png/7591278.png)
چکیده انگلیسی
Solanum paniculatum L. (Solanaceae) is a plant species widespread throughout tropical America, especially in the Brazilian Savanna region. It is used in Brazil for culinary purposes and in folk medicine to treat liver and gastric dysfunctions, as well as hangovers. Fractionation of the ethanolic extracts (70%) from aerial parts (leaves and twigs) of S. paniculatum led to the isolation of the two new saponins (22R, 23S, 25R)-3β, 6α, 23-trihydroxy-5α-spirostane 6-O-β-d-xylopyranosyl-(1â³â³Â â 3â³â²)-O-[β-d-quinovopyranosyl(1â³â²Â â 2â²)]-O-[α-l-rhamnopyranosyl(1â³Â â 3â²)]-O-β-d-quinovopyranoside (1) and diosgenin 3-O-β-d-glucopyranosyl(1â³Â â 6â²)-O-β-d-glucopyranoside (2) together with four know compounds: caffeic acid (3), diosgenin β-d-glucopyranoside (4), rutin (5), and quercetin 3-O-α-l-rhamnopyranosyl (1â³â²Â â 6â³)-O-β-d-galactopyranoside (6). The structures of these compounds were elucidated by extensive use of 1D and 2D NMR experiments along with HRESIMS analyses. Different doses (31.25-500 mg/kg) of ethanolic extract of leaves from S. paniculatum were evaluated against gastric ulcer induced by ethanol in rats. The lower dose of extract able to promote antiulcer effect was 125 mg/kg. The treatment with S. paniculatum by oral route was able to decrease gastric lesion area and also reduced levels of myeloperoxidase (MPO) in the gastric mucosa. Our results reveal for the first time, steroidal saponins from S. paniculatum and the antiulcer effect of this species at this lower dose.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 186, 1 November 2015, Pages 160-167
Journal: Food Chemistry - Volume 186, 1 November 2015, Pages 160-167
نویسندگان
Gerardo Magela Vieira Júnior, Cláudia Quintino da Rocha, Tamires de Souza Rodrigues, Clélia Akiko Hiruma-Lima, Wagner Vilegas,